- Salvage Disposal Service, Murphysboro
- Sandwich Shop Restaurants, Murphysboro
- Satellite Dish Antennas & Equipment Dealers, Murphysboro
- Scrap & Waste Machinery, Murphysboro
- Scrap & Waste Materials, Murphysboro
- Screen Printing, Murphysboro
- Secondary Schools, Murphysboro
- Secretarial & Court Reporting Services, Murphysboro
- Security Brokers & Dealers, Murphysboro
- Security Guard & Patrol Service, Murphysboro - Bodyguard, Guard Dogs, Etc
- Security Investigative Services, Murphysboro
- Security Services, Murphysboro
- Senior Citizens Service & Health Organizations, Murphysboro
- Septic Tank Installation & Repair, Murphysboro - Septic Systems
- Septic Tank Pumping & Cleaning, Murphysboro - Septic Systems
- Septic Tanks & Septic Systems Contractors, Murphysboro - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Murphysboro - Wholesale, Dealers & Suppliers
- Sewer & Drain Cleaning & Repair, Murphysboro - Drain Cleaner & Installation Services
- Sheet Metal Contractors, Murphysboro - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Murphysboro
- Sheriff's Department, Murphysboro
- Shopping & Shopping Services, Murphysboro
- Signs, Murphysboro
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- Skin Care & Cosmetology Salons, Murphysboro
- Skin Care Products & Treatments, Murphysboro
- Sleep Doctors, Murphysboro - Specialists, Physicians & Surgeons (Sleep Medicine)
- Small Appliances, Murphysboro
- Snow Removal Services, Murphysboro - Snow Plow Service
- Social Services & Welfare, Murphysboro
- Societies & Foundation Associations, Murphysboro
- Special Education & Care, Murphysboro
- Special Interest Schools Or Instruction, Murphysboro
- Speciality Food Stores, Murphysboro
- Specialty Goods Storage, Murphysboro
- Specialty Stores, Murphysboro
- Sporting Goods Stores, Murphysboro
- State Government, Murphysboro
- Steel & Metal Goods, Murphysboro - Steel Distributors
- Stocks & Bond Brokers, Murphysboro
- Stoves & Furnace Equipment, Murphysboro - Fittings & Repair Parts
- Submarine Sandwich Restaurants, Murphysboro
- Substance Abuse Clinics, Murphysboro - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Murphysboro - Surveying Service
- Surveyors, Murphysboro
- Swimming Pools Repair, Service, Supplies, Sale & Installation, Murphysboro
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