- Dairy Products - Wholesale & Retail, Murphysboro
- Deck, Patio & Gazebo Design, Building, Cleaning, Repair & Maintenance Contractors, Murphysboro
- Decorative & Stamped Concrete, Murphysboro
- Delicatessen Restaurants, Murphysboro
- Denomination, Non-Denominational, Etcetera, Murphysboro
- Dentists, Murphysboro
- Department Stores, Murphysboro
- Dermatologists, Murphysboro - Skin Doctors, Physicians & Surgeons (Dermatology)
- Digital Imaging Photographers, Murphysboro
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- Dirt, Murphysboro
- Disaster Preparedness Equipment & Supplies, Murphysboro
- Discount Stores, Murphysboro - Clothing, Grocery, Furniture, Etc
- Divorce & Family Law Attorneys & Lawyers, Murphysboro
- Doctors, Physicians & Surgeons, Murphysboro
- Doll Repair & Restoration, Murphysboro
- Dolls, Doll Houses & Accessories , Murphysboro
- Drinking Establishments, Murphysboro
- Dumpster Rental, Murphysboro
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