- Sand Gravel & Aggregate, Vandalia
- Sandwich Shop Restaurants, Vandalia
- Satellite TV Service, Vandalia
- Savings & Loan Associations, Vandalia
- Savings Banks, Vandalia
- Scrap & Waste Machinery, Vandalia
- Scrap & Waste Materials, Vandalia
- Screen Printing, Vandalia
- Seafood Restaurants, Vandalia
- Seals, Vandalia - Hermetic, Hydraulic, Mechanical, Metal, Oil, Grease, etc
- Secondary Schools, Vandalia
- Security Brokers & Dealers, Vandalia
- Senior Citizens Service & Health Organizations, Vandalia
- Septic Tank Installation & Repair, Vandalia - Septic Systems
- Septic Tank Pumping & Cleaning, Vandalia - Septic Systems
- Septic Tanks & Septic Systems Contractors, Vandalia - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Vandalia - Wholesale, Dealers & Suppliers
- Sewer & Drain Cleaning & Repair, Vandalia - Drain Cleaner & Installation Services
- Sewing Machine Repair & Service, Vandalia
- Sewing Machines, Equipment & Supplies, Vandalia
- Shopping & Shopping Services, Vandalia
- Siding Contractors, Vandalia - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Small Appliances, Vandalia
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- Snacks & Desserts, Vandalia
- Social Services & Welfare, Vandalia
- Special Education & Care, Vandalia
- Special Events Photographers, Vandalia
- Specialty Goods Storage, Vandalia
- Specialty Stores, Vandalia
- Staffing & Support Services, Vandalia
- State Government, Vandalia
- Steak House Restaurants, Vandalia
- Steel & Metal Goods, Vandalia - Steel Distributors
- Steel Manufacturers, Vandalia
- Steel Mills & Blast Furnaces, Vandalia
- Steel Products, Vandalia
- Stocks & Bond Brokers, Vandalia
- Stoves & Furnace Equipment, Vandalia - Fittings & Repair Parts
- Submarine Sandwich Restaurants, Vandalia
- Substance Abuse Clinics, Vandalia - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Surveyor Services, Vandalia - Surveying Service
- Swimming Pool, Sauna & Spa Contractors, Vandalia
- Swimming Pools, Vandalia
- Swimming Pools Contractors, Vandalia - Install Inground - Above Ground Pools
- Swimming Pools Supplies, Equipment & Accessories, Vandalia
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