- Dance Companies, Effingham
- Data Communications Service, Equipment, Supplies & Sales, Effingham
- Day Spas, Effingham
- Deck, Patio & Gazebo Design, Building, Cleaning, Repair & Maintenance Contractors, Effingham
- Decorating & Designing Services, Effingham
- Delivery & Errand Services, Effingham
- Dental Bonding & Cosmetic Dentistry, Effingham - Cosmetic Dentist & Tooth Bonding
- Dental Clinics, Effingham
- Dental Supplies & Equipment, Effingham
- Dentists, Effingham
- Department Stores, Effingham
- Developmental Disabilities, Effingham
- Dialysis Clinics, Effingham - Kidney Dialysis Centers
- Diesel Engine Repair & Service, Effingham
- Direct Mail Advertising Services, Effingham
- Disability And Social Security Attorneys & Lawyers, Effingham
- Disabled Persons Assistive Services, Effingham
- Discount Stores, Effingham - Clothing, Grocery, Furniture, Etc
- Disease, Handicap & Disability Services, Organizations & Groups, Effingham
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- Dishwashers Sales, Service & Repair, Effingham
- Dispensing Machines, Effingham
- Divorce & Family Law Attorneys & Lawyers, Effingham
- Dock Construction - Build & Repair, Effingham - Dock Builders
- Doctors, Physicians & Surgeons, Effingham
- Donuts, Effingham
- Door & Gate Operating Devices, Effingham
- Doors & Door Frames, Effingham - Exterior, Interior, French, Front Entry, Patio, Storm, Garage & Sliding Glass Doors
- Drinking Establishments, Effingham
- Drugs, Pharmaceutical Products & Toiletries - Wholesale & Manufacturers, Effingham
- Dry Cleaning & Laundry, Effingham - Dry Cleaners
- Drywall Contractors, Effingham - Drywall Repair & Installation Services
- Drywall, Insulation & Plaster Contractors, Effingham - Installation & Repair Services
- DUI Attorneys & Lawyers, Effingham - DWI - Drunk Driving
- DUI Attorneys & Lawyers, Effingham - DWI - Drunk Driving
- DUI Lawyers & Attorneys, Effingham - DWI - Drunk Driving
- Dump Truck, Effingham
- Dumpster Rental, Effingham
- Durable & Non Durable Goods & Products, Effingham
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