- Safe, Lock & Key Repair Services, Edwardsville - Safes & Vaults Opening & Repair
- Safety & Security Systems & Consultants, Edwardsville
- Sales & Marketing Consultant, Edwardsville
- Sales Promotion Service, Edwardsville
- Sand Gravel & Aggregate, Edwardsville
- Sandwich Shop Restaurants, Edwardsville
- Satellite Dish Antennas & Equipment Dealers, Edwardsville
- Savings Banks, Edwardsville
- Scrap & Waste Materials, Edwardsville
- Screen Houses, Edwardsville
- Secondary Schools, Edwardsville
- Secretarial & Court Reporting Services, Edwardsville
- Security Alarm Systems - Home & Business, Edwardsville
- Security Brokers & Dealers, Edwardsville
- Security Control Systems & Monitoring, Edwardsville - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Investigative Services, Edwardsville
- Security Services, Edwardsville
- Senior Citizens Service & Health Organizations, Edwardsville
- Septic Tank Installation & Repair, Edwardsville - Septic Systems
- Septic Tank Pumping & Cleaning, Edwardsville - Septic Systems
- Septic Tanks & Septic Systems Contractors, Edwardsville - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Edwardsville - Wholesale, Dealers & Suppliers
- Sewer & Drain Cleaning & Repair, Edwardsville - Drain Cleaner & Installation Services
- Sewer Construction Contractors, Edwardsville - Sewer Line, Pipe Installation & Repair Services
- Sewing & Yarn Stores & Supplies, Edwardsville
- Sheriff's Department, Edwardsville
- Shoe Stores, Edwardsville - Mens, Womens & Kids Shoes
- Shooting & Target Ranges, Edwardsville
- Shopping & Shopping Services, Edwardsville
- Siding Contractors, Edwardsville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Sign Equipment & Supplies, Edwardsville
- Sign Hanging & Installation Service, Edwardsville - Signs Erectors & Hangers
- Signs, Edwardsville
- Signs Magnetic, Edwardsville
- Sleep Doctors, Edwardsville - Specialists, Physicians & Surgeons (Sleep Medicine)
- Small Appliances, Edwardsville
- Snacks & Desserts, Edwardsville
- Snowmobile Dealers, Edwardsville - Parts, Gear, Clothing & Accessories
- Social Security And Disability Attorneys & Lawyers, Edwardsville
- Social Security And Disability Lawyers & Attorneys, Edwardsville
- Social Security Counselors & Representatives, Edwardsville
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- Social Services & Welfare, Edwardsville
- Societies & Foundation Associations, Edwardsville
- Sod & Sodding Service, Edwardsville
- Sound Systems, Microphones & Equipment, Edwardsville
- Special Events & Party Supply Rental, Edwardsville
- Special Interest Schools Or Instruction, Edwardsville
- Specialty Animal Services, Edwardsville
- Specialty Goods Storage, Edwardsville
- Specialty Stores, Edwardsville
- Speech & Hearing Specialists, Edwardsville
- Sporting & Recreational Camps, Edwardsville
- Sporting Goods Stores, Edwardsville
- Sports & Recreational Services, Edwardsville
- Sports Clubs, Edwardsville
- Sports Medicine, Edwardsville - Doctors, Physicians & Surgeons
- Sportswear Clothing Stores, Edwardsville - Sports Clothes
- Spraying Booths & Equipment, Edwardsville
- Staffing & Support Services, Edwardsville
- State Government, Edwardsville
- Steak House Restaurants, Edwardsville
- Steel & Metal Goods, Edwardsville - Steel Distributors
- Steel Manufacturers, Edwardsville
- Stock & Bond Brokers & Dealers, Edwardsville
- Stocks & Bond Brokers, Edwardsville
- Stone, Edwardsville
- Stoves & Furnace Equipment, Edwardsville - Fittings & Repair Parts
- Structural Steel Erection, Edwardsville
- Submarine Sandwich Restaurants, Edwardsville
- Substance Abuse Clinics, Edwardsville - Alcoholism, Addiction & Drug Abuse Treatment Centers
- Summer Camps, Edwardsville
- Sunrooms & Solarium Construction Contractors, Edwardsville - Build & Repair
- Sunrooms, Greenhouses, Solariums & Atrium Builders, Edwardsville - Build & Repair
- Surgical Supplies & Equipment, Edwardsville
- Surveyor Services, Edwardsville - Surveying Service
- Surveyors, Edwardsville
- Sushi Restaurants, Edwardsville
- Swimming Pool Covers & Enclosures, Edwardsville
- Swimming Pool, Sauna & Spa Contractors, Edwardsville
- Swimming Pools Contractors, Edwardsville - Install Inground - Above Ground Pools
- Swimming Pools Supplies, Equipment & Accessories, Edwardsville
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