- Safety & Security Systems & Consultants, Bethalto
- Sandwich Shop Restaurants, Bethalto
- Satellite & Cable TV Equipment & Systems Repair & Service, Bethalto
- Satellite Dish Antennas & Equipment Dealers, Bethalto
- Screen Printing, Bethalto
- Seafood Restaurants, Bethalto
- Secondary Schools, Bethalto
- Security Brokers & Dealers, Bethalto
- Senior Citizens Service & Health Organizations, Bethalto
- Shirts & T-Shirts, Bethalto
- Shopping & Shopping Services, Bethalto
- Skin Care & Cosmetology Salons, Bethalto
- Skin Care Products & Treatments, Bethalto
- Social Services & Welfare, Bethalto
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- Special Events & Party Supply Rental, Bethalto
- Specialty Animal Services, Bethalto
- Specialty Goods Storage, Bethalto
- Specialty Stores, Bethalto
- Sports Clubs, Bethalto
- Staffing & Support Services, Bethalto
- Stamp Collecting & Coin Dealers , Bethalto
- Stocks & Bond Brokers, Bethalto
- Submarine Sandwich Restaurants, Bethalto
- Surveyor Services, Bethalto - Surveying Service
- Swimming Pool, Sauna & Spa Contractors, Bethalto
- Swimming Pools Contractors, Bethalto - Install Inground - Above Ground Pools
- Swimming Pools Supplies, Equipment & Accessories, Bethalto
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