- Sandwich Shop Restaurants, Shelbyville
- Satellite Dish Antennas & Equipment Dealers, Shelbyville
- Savings & Loan Associations, Shelbyville
- Savings Banks, Shelbyville
- Screen Printing, Shelbyville
- Seafood Restaurants, Shelbyville
- Secondary Schools, Shelbyville
- Security Brokers & Dealers, Shelbyville
- Seeds & Bulbs Wholesale & Growers, Shelbyville
- Senior Citizens Service & Health Organizations, Shelbyville
- Septic Tank Installation & Repair, Shelbyville - Septic Systems
- Septic Tank Pumping & Cleaning, Shelbyville - Septic Systems
- Septic Tanks & Septic Systems Contractors, Shelbyville - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Shelbyville - Wholesale, Dealers & Suppliers
- Service Establishment Supplies & Equipment, Shelbyville
- Sewer & Drain Cleaning & Repair, Shelbyville - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, Shelbyville
- Sheet Metal Contractors, Shelbyville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Shelbyville
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- Sheriff's Department, Shelbyville
- Shopping & Shopping Services, Shelbyville
- Signs, Shelbyville
- Snacks & Desserts, Shelbyville
- Social Services & Welfare, Shelbyville
- Societies & Foundation Associations, Shelbyville
- Special Events & Party Supply Rental, Shelbyville
- Special Interest Schools Or Instruction, Shelbyville
- Specialty Animal Services, Shelbyville
- Specialty Stores, Shelbyville
- Sprinkler Alarm Systems, Shelbyville - Fire Sprinkler Systems
- Staffing & Support Services, Shelbyville
- Stamp Collecting & Coin Dealers , Shelbyville
- State Government, Shelbyville
- Stitching Services, Shelbyville
- Stock & Bond Brokers & Dealers, Shelbyville
- Stocks & Bond Brokers, Shelbyville
- Stoves & Furnace Equipment, Shelbyville - Fittings & Repair Parts
- Submarine Sandwich Restaurants, Shelbyville
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